"I hope I live up to this recognition and continue discovering amazing things," List told reporters after being announced as a winner. "Benjamin List has opened a new chapter in catalysis research with great application potential. Let us know if you have suggestions to improve this article (requires login). 2000, 122, 17, 42434244 Scientists had previously believed that there were just two types of catalysts: metals and enzymes. The Nobel Prize Ceremony at the Harnck Haus. Benjamin List and David WC MacMillan won the 2021 Nobel Prize in Chemistry for the development of asymmetric organocatalysis. Just as our two hands have five fingers, these molecules also resemble each other in structure at first glance.

Am. [18][19][20] The development is based on the HajosParrishEderSauerWiechert reaction. However, this is the route that pharmaceutical companies usually take. He returned to Germany in 2003 to become a research group leader at the Max Planck Institute for Coal Research, Mlheim an der Ruhr, and in 2005 he became director of the institute. Am. Catalysis researcher Benjamin List is Director at the Max-Planck-Institut fr Kohlenforschung in Mlheim an der Ruhr, Germany. He has succeeded for the first time in developing organic catalysts with high stereoselectivity - a breakthrough rarely seen. "[2] The development has great influence on pharmaceutical research and the drug production and "made chemistry greener". ", Cheng likened it to making food. Otherwise, the consequences can be fatal, as the thalidomide scandal in the early 1960s showed. J. Get a Britannica Premium subscription and gain access to exclusive content. Chem. Benjamin List was born in Frankfurt am Main in 1968, into a family with quite a remarkable tradition in the natural sciences: his great-great-grandfather was the chemist Jacob Volhard, whom at least all chemistry students know. Giddy about geology?

2009, 131, 33, 1164011641 The 2020 Nobel in Chemistry was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna for the development of a method for genome editing. Watch CNN's report, UK swelters in what could be hottest day ever, Video: Pilot deploys parachute, plane crashes into sidewalk outside Bruges, 'Hasta la vista, baby': Boris Johnson bows out to lawmakers' applause, Italian authorities: '70% of crops are gone' in Po River Delta, Saudi foreign minister discusses conversations with Biden about Iran, This country is preparing for Russia to cut off its gas supply soon, Controversial church under the microscope after assassination, The environmental cost of the Russia-Ukraine conflict, Saudi FM responds to Biden's fist bump with the Crown Prince, Spain's heat wave death toll climbs to 84, Nobel Prize in physics awarded to scientists whose work warned the world of climate change. Catalysts are fundamental tools for chemists, but researchers long believed that there were, in principle, just two types of catalysts available: metals and enzymes. Why Bhupinder Singh distanced himself from Hindi songs in the 80s, 4 people held for offering namaz in Lucknow's Lulu Mall, Janhvi Kapoor wishes to work in South films, says 'they are at the top of their game' | Exclusive, Kallakurichi violence: Tamil Nadu govt transfers district collector, SP, Indian High Commissioner Gopal Baglay on Sri Lanka crisis, India's assistance and more, Fire breaks out in residential building in Delhi's New Ashok Nagar, 12 people rescued. The Nobel Prize in Chemistry 2021 is awarded jointly to Benjamin List and David W. C. MacMillan for their work in the development of asymmetric organocatalysis, a method that uses small organic molecules as catalysts instead of enzymes or metals. They have established for the first time that small organic molecules are suitable as mediators of chemical reactions. Dr. So say it takes 10 minutes to produce a steak. Read More About the Nobel Prize in Chemistry 2021 in C&EN, Journal of the American Chemical Society (JACS). The methods pioneered by List and MacMillan have allowed synthesis of important molecules without the intensive use of environmentally damaging heavy metals. He then returned to Germany, where he became a group leader at the Max-Planck-Institut fr Kohlenforschung, and one of its directors in 2005. The scientists contributed to the understanding of global complex systems like climate. DOI: 10.1021/ja973676b, The Direct Catalytic Asymmetric Three-Component Mannich Reaction Ostwald demonstrated that certain substances in this case, acids and bases can speed up chemical reactions without becoming a part of the final product. Benjamin List, (born January 11, 1968, Frankfurt am Main, West Germany [now in Germany]), German chemist who was awarded the 2021 Nobel Prize for Chemistry for his work on asymmetric organocatalysis. [10][11] List is also a principal investigator at the Institute for Chemical Reaction Design and Discovery, Hokkaido University since 2018. Asymmetric Enamine Catalysis Dr. DOI: 10.1021/ja025981p, The First Enantioselective Organocatalytic MukaiyamaMichael Reaction: A Direct Method for the Synthesis of Enantioenriched -Butenolide Architecture [7][8] List worked at the Scripps Research Institute Department of Molecular Biology in La Jolla, US as a postdoctoral researcher in Carlos F. Barbas III and Richard Lerner's research groups[9] from 1997 to 1998 with a scholarship from the Alexander von Humboldt Foundation[3] and as an assistant professor from 1999 to 2003. Benjamin List and David MacMillan are announced as winners of the 2021 Nobel prize in chemistry, at the Royal Swedish Academy of Sciences in Stockholm on October 6. "This is a fantastically important piece of chemistry and these two are undoubtedly leaders in that field," Phillip Broadwith, business editor of Chemistry World magazine, told CNN after the announcement was made. Benjamin List, a Specially Appointed Professor of the Institute for the Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, was awarded the Nobel Prize in Chemistry 2021 in a ceremony held in Berlin, Germany on December 7, 2021, followed by his Nobel Lecture on the next day. Benjamin List was born in Frankfurt, Germany in 1968, into a family with scientific roots; his great-great-grandfather Jacob Volhard was a famous chemist, his great-grandfather Franz Volhard was a nephrologist, and his aunt Christiane Nsslein-Volhard a developmental biologist and herself a Nobel Laureate in Physiology or Medicine in 1995. Chem. To trick counterfeiters, Benjamin Franklin deliberately misspelled Pennsylvania when printing official currency for the American colony. [18][19] This takes place in intermolecular aldol reactions, in which carbon atoms from two different molecules are bonded together, induced by proline. I would like to quickly disseminate it among the wonderful people I had the chance to work with over the two decades. He thanked all who worked in the field of asymmetric organocatalysis, saying, It only became a field thanks to hundreds of groups around the world, thousands of chemists. He also thanked the Max Planck Society for giving him the opportunity to head his own department when he was only 36 years old, which was vital to his discoveries; and finally thanked his family for all their support. Sign up for CNN's Wonder Theory science newsletter. The cooking is much better, much faster, much cheaper. [21][22] Subsequently, he developed the first proline-catalyzed Mannich,[23] Michael,[24] and -amination reactions. [25][26] He found asymmetric catalysis (especially Asymmetric counteranion directed catalysis, ACDC). But for the second time in three years, no women were recognized in the scientific awards. 2003, 125, 5, 11921194 The prizes for literature and peace will be announced later this week, before the economics award concludes the annual festivities on Monday. "In its essence, it's about making molecules and it's about making them more efficiently, using less energy and without metal catalysts, which are problematic if they end up in pharmaceuticals. Organocatalysis became a game-changer in the synthesis of organic compounds, fine chemicals and natural products, not to mention pharmaceuticals. The Nobel Prize in Chemistry is awarded by the Royal Swedish Academy of Sciences, Stockholm, Sweden. The Academy said that Benjamin List, professor at the Max Plack Institute in Germany, and David MacMillan, who is currently with Princeton University, in 2000, independent of each other, developed a third type of catalysis. List considered that enzymes also drive chemical reactions but were not metals as other catalysts were and that only a few amino acids in an enzyme would be involved in the chemical reaction. Chemistry Nobel Prize 2021 for Benjamin List, International Prize for Translational Neuroscience, International Max Planck Research Schools, Max-Planck-Institut fr Kohlenforschung, Mlheim an der Ruhr, Krber European Science Prize 2022 for Anthony Hyman, Gruber Cosmology Prize for Frank Eisenhauer, Bones, constructed like prestressed concrete, Max Planck spin-off Meshcapade wins new startup award, Homogeneous hydrogenolysis with molecular palladium. The committee credited them with "bringing the greatest benefit to humankind.". Am. The duo developed a precise new tool for molecular construction, which had a great impact on pharmaceutical research, and has made chemistry greener. Nupur Sharma gets interim relief from SC: Are multiple FIRs the new weapon to harass? DOI: 10.1021/ja029095q, Enantioselective -Arylation of Aldehydes via Organo-SOMO Catalysis. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Copyright 2022 American Chemical Society Privacy Policy. J. He went on to study for his PhD degree under Professor Johann Mulzer at the University of Frankfurt, working on the synthesis of vitamin B12. In 1909, Wilhelm Ostwald was awarded the prize for his work on catalysis. In 1999, Benjamin List successfully used the amino acid proline in a rationally designed catalytic reaction. DOI: 10.1021/ja015717g, New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic DielsAlder Reaction New method enables simple tritium labeling and could provide added value to the discovery and development of pharmaceuticals, Marietta Auer and Iain Couzin are awarded the Leibniz Prize 2022 of the German Research Foundation DFG. In the case of molecules that have two forms, one being the mirror image of the other but sometimes having undesirable effects, asymmetric organocatalysis can be used to produce the preferred form, whereas previous methods of synthesis would produce both. But like the fingers, the individual components of chiral molecules are arranged in mirror image. "We are inviting more women to be nominators and so on. The prize comes with an amount of 10 million Swedish kronor, to be shared equally between the laureates. He became an assistant professor there in 1998. 2002, 124, 20, 56565657 J. Video provided by Nobel Prize Outreach. ", "As chemists we love to do reactions and reactions are a key part of our work, and the reactions frequently are unfortunately not as desired -- they can be slow, they can be nonspecific they may not go the way we wanted," he told CNN. In this way, organocatalysts are bringing the greatest benefit to humankind," the Academy said in a statement. Soc. [18] Asymmetric organocatalysis[26] is particularly important in bioactive organic compounds, where the chirality of the compounds is important, for example in drug production. Shortly after List published his research on proline in 2000, David MacMillan published the results of a similar reaction and first used the phrase organocatalysis. At first, however, he was rather unsure whether it was a useful experiment: "I was completely unsure. Previously, in chemistry, biology and pharmacy, it was thought that only enzymes or elaborately built catalysts containing metals, and often expensive or toxic ones, had this selective effect. After expressing his deep gratitude to the Royal Swedish Academy of Sciences and all attendees, Dr. In organocatalysis, the catalysis takes place using small organic molecules instead of metals. List said he was having a coffee with his wife when he got the call from the Nobel Committee. The discovery that small organic molecules are excellent catalysts makes Ben List, Director at the Max-Planck-Institut fr Kohlenforschung, one of the pioneers of a new research field in chemistry. However, many catalysts produce both forms of a chiral molecule equally. J. "Sweden appears on my phone, and I look at her, she looks at me and I run out of the coffee shop to the street and, you know, that was amazing. [10][11], In 2003 he returned to Germany to become group leader at the Max Planck Institute for Coal Research, and in 2005 he became one of the institute's directors, heading the Homogeneous Catalysis Department. The other form of thalidomide, however, caused malformations in newborns. List delivered his Nobel Lecture, Asymmetric Organocatalysis. J. Chem. Shiv Sena MP Rahul Shewale says no split in party, Copyright 2022 Living Media India Limited. And Christiane Nsslein-Volhard, herself a Max Planck Director and Nobel Prize winner in physiology and medicine, can now congratulate her nephew on also winning the Nobel Prize in Chemistry. DOI: 10.1021/ja005517p, New Strategies in Organic Catalysis: The First Enantioselective Organocatalytic FriedelCrafts Alkylation One form of the active ingredient thalidomide had a sedative effect and was also administered against nausea during pregnancy. The process is simpler, cheaper and much more accessible, not to mention less harmful to the environment. If I can do it in 10 seconds, that'd be much better. Chem. DOI: 10.1021/ja001923x, Direct Catalytic Asymmetric -Amination of Aldehydes And last year, Emmanuelle Charpentier and Reinhard Genzel, two researchers from the Max Planck Society, were also awarded the highest science accolade. List said, The Nobel prize is almost too much for a single person. The following day, Dr. "This is very fundamental chemistry," Broadwith added. And that's exactly what catalysis is doing now. [15] As of 2021[update], he has an h-index of 95 according to Google Scholar[16] and of 86 according to Scopus. It's a long and strategic work," he told CNN. The list of laureates includes the likes of Marie Curie, who was awarded Nobel in recognition of her services to the advancement of chemistry by the discovery of the elements radium and polonium, by the isolation of radium and the study of the nature and compounds of this remarkable element. Soc. Explore the universe with news on fascinating discoveries, scientific advancements and more. The announcement comes a day after the Academy awarded the 2021 Nobel in Physics to Syukuro Manabe, Klaus Hasselmann, Giorgio Parisi jointly for groundbreaking contributions to our understanding of complex physical systems. Customers would like it, the chef would like it.

DOI: 10.1021/ja994280y, New Strategies for Organic Catalysis: The First Enantioselective Organocatalytic 1,3-Dipolar Cycloaddition Updates? DOI: 10.1021/ja0261325, Enamine Catalysis Is a Powerful Strategy for the Catalytic Generation and Use of Carbanion Equivalents Soc. So far 186 people have been recognised by the Royal Swedish Academy of Sciences for their contribution in the field of which seven are women. Am. 2000, 122, 40, 98749875 J. Currently, there is hardly any chemical product that doesnt require catalysis in its production process. DOI: 10.1021/ja000092s, The Enantioselective Organocatalytic 1,4-Addition of Electron-Rich Benzenes to ,-Unsaturated Aldehydes Benjamin List receiving his Nobel Prize medal and diploma in Berlin, Germany at Harnack House, Max Planck Society for the Advancement of Science. The technology has had a revolutionary impact on the life sciences contributing to new cancer therapies. The work of 2001 Laureates William S. Knowles, Ryoji Noyori and K. Barry Sharpless on asymmetric catalysis, is most closely related to Dr. Lists research. In asymmetric catalysis, where only one of the two variants is produced, the discoveries of Benjamin List and Davin McMillan have opened up completely new possibilities. J. Acc. List ended by acknowledging all the support he has received through the years from coworkers, institutions, funding agencies and his family. ", "Crowd-based peer review can be good and fast", "Scopus preview List, Benjamin Author details Scopus", "DFG gratuliert Benjamin List zum Nobelpreis fr Chemie", "Chemie-Nobelpreis fr "geniales Werkzeug", "Ehemaliger Berliner Student Benjamin List gewinnt Chemie-Nobelpreis", "Katalysator-Forscher List: Respektlos zum Nobelpreis", "The Nobel Prize in Chemistry 2021, Benjamin List Interview", "Benjamin List: Der Nobelpreistrger, der den Tsunami berlebte", "Diplom an der Freien Universitt Berlin: Mller gratuliert Chemie-Nobelpreistrgern List und McMillan", "Professor Ben List erhlt den Herbert C. Brown Award", https://en.wikipedia.org/w/index.php?title=Benjamin_List&oldid=1095376397, Members of the German Academy of Sciences Leopoldina, Short description is different from Wikidata, Articles containing potentially dated statements from 2021, All articles containing potentially dated statements, Nobelprize template using Wikidata property P8024, Creative Commons Attribution-ShareAlike License 3.0, 2004 Lecturers Award of the Fonds der Chemischen Industrie, 2005 AstraZeneca European Lectureship, the Society of Synthetic Chemistry, Japan, 2007 AstraZeneca Award in Organic Chemistry, 2007 Award of the Fonds der Chemischen Industrie, 2009 Boehringer-Ingelheim Lectureship, Canada, 2012 Novartis Chemistry Lectureship Award, 2014 Thomson Reuters Highly Cited Researcher. Written by Sohail Keegan Pinto and Naoki Namba, Dr. Benjamin Lists Thoughts and Messages upon Winning the 2021 Nobel Prize in Chemistry, Hokkaido University congratulates Dr. Benjamin List for winning Nobel Prize in Chemistry | Hokkaido University, Dr. Benjamin List, a Specially Appointed Professor at Hokkaido University, was awarded the Nobel Prize in Chemistry, Kita 8, Nishi 5, Kita-ku,Sapporo, Hokkaido,060-0808 Japan+81-11-716-2111, Career Path Support for PhD Students and Postdocs, Promotion office of Research environment for Diversity (Ree-D), Hokkaido University Translated Information Archiving Database (HUTRIAD), Hokudai Alumni Associations Across Japan and the World, Hokkaido University Ambassador and Partner System, Hokkaido Universal Campus Initiative (HUCI), Global Institution for Collaborative Research and Education (GI-CoRE), Institute for Chemical Reaction Design and Discovery (ICReDD), Resources for Researchers during the COVID-19 Pandemic, Double Degree, Cotutelle & Joint Degree Programs, Institute for International Collaboration, Benjamin List Receives Nobel Prize in Chemistry 2021. Benjamin List (German pronunciation: [bnjamin lst] (listen); born 11 January 1968) is a German chemist who is one of the directors of the Max Planck Institute for Coal Research and professor of organic chemistry at the University of Cologne. A portrait of the director at the Max-Planck-Institut fr Kohlenforschung and 2021 Nobel laureate in chemistry. Between 1993 and 2003, he did research at the Scripps Research Institute in La Jolla, USA. Until then, only metal catalysts and enzymes were known to facilitate asymmetric reactions. [7] He has held a part-time position as an honorary professor of organic chemistry at the University of Cologne since 2004. Soc. [13][14] He is the editor-in-chief of the scientific journal Synlett. Soc. In this case, however, one form is converted into the other in the body, so it would not have helped to use only the variant with the desired effect. [27][28] He developed also new methods of textile organic catalysis, in which soluble organic catalysts and textiles are bound. Such molecules are involved in all biological processes and also play an important role as medical agents. Toward Universal Catalysts for Selective Synthesis (2022), Council for the Lindau Nobel Laureate Meetings/Foundation Lindau Nobel Laureate Meetings. An Ortho-Selective Arylation Reaction Based on an Open-Shell Pathway Dr. Shortly afterwards, ammonia synthesis became the first large-scale industrial process using catalysis (Haber-Bosch process). In the lecture, Dr. List and Dr. MacMillan independently developed small organic molecules that can catalyze asymmetric reactions, processes to produce one of two molecules that are mirror images to each other. MacMillanwon the Gabor A. Somorjai Award for Creative Research in Catalysis in 2018, the ACS Award for Creative Work in Synthetic Organic Chemistry in 2011, the Arthur C. Cope Scholar Award in 2007, and the Elias J. Corey Award for Outstanding Original Contribution in Organic Synthesis by a Young Investigator in 2005. 2017 Prof. U. R. Ghatak Endowment Lecture, 2017 Ta-shue Chou Lectureship, Institute of Chemistry, Academia Sinica, Taipei, Taiwan, 2021 TCR Lecture,100th CSJ Annual Meeting, Japan, 2022 Herbert C. Brown Award 2022 for Creative Research in Synthetic Methodes, This page was last edited on 28 June 2022, at 01:04.

While every effort has been made to follow citation style rules, there may be some discrepancies. "[3], HajosParrishEderSauerWiechert reaction, Asymmetric counteranion directed catalysis, University of Illinois at Urbana-Champaign, Indian Association for the Cultivation of Science, German National Academy of Sciences Leopoldina, "Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes", "Nobelpreis fr Nsslein-Volhards Neffen", "Nobelpreis an Deutschen fr Revolution in der Chemie", "Benjamin List, Direktor am Max-Planck-Institut fr Kohlenforschung, erhlt ERC Advanced Grant des Europischen Forschungsrates", "Nobel honors molecule builders who made chemistry easier and greener", "ICReDD Principal Investigator, Prof. Benjamin List won the Nobel Prize in Chemistry 2021!!